Xiangxi Wang

Xiangxi Wang focuses on major national public health needs and carries out systematic research on the structure and function of virus particles directly related to important infectious diseases, revealing the process of virus infection and immune mechanisms. Wang attaches great importance to the combination of basic scientific research and clinical application, and conducts targeted scientific research in that he not only analyzes the fine structure of important virus whole particles but also applies the structural features to the development and quality control of novel vaccines as well as the development of supersensitive diagnostic technology.    

Wang has led his team to achieve multiple important results in related fields: accelerated the development of SARS-CoV-2 inactivated vaccine CoronaVac by undertaking the design and optimization of the purification process of the inactivated virus, the analyses of the structural characteristics, key epitopes, and stability, involved in the quality control of the vaccine in clinical trials, providing key technical support for the smooth implementation of the vaccine. As well as the development of multiple SARS-CoV-2 therapeutic antibodies and multi-epitope antibody cocktail therapy, some of which has entered clinical trials overseas; developed super-sensitive SARS-CoV-2 neutralization antibody diagnosis technology, which obtained the sample inspection number from the Chinese National Institutes for Food and Drug Control. He also determined for the first time in the world, the unique five-layer structural characteristics of the African swine fever virus, revealing a variety of potential protective antigens and epitope information on the key antigens of this virus, proposed the assembly mechanism of African swine fever virus and designed virus-like particle recombinant vaccine, and the protection efficiency of which is at present being verified in animals.    

Wang's multidisciplinary research system renders him unique among international and domestic counterparts, not only for the development of basic disciplines but also for the improvement of innovation capabilities to address major national needs.