Cancer is a disease
with abnormal cell proliferation. Conventional treatments include physical
therapy, chemotherapy, radiation therapy, and surgery. However, they are always
accompanied by sever side effect. Cures are typically rare until recent
success in immunotherapy.
The immune system in the human body is like a guard guarding the master's health. When pathogens invade,
the immune system is activated and eliminates the "invaders" without
mercy. But to cancer cells, the "traitors" from our own body, the immune
system is easily blinded.
Is it possible to kill cancer cells by restoring or activating the body's own immune system? Based
on this idea, in the past decades, immunotherapies including cancer vaccines,
immune checkpoint inhibitors, and adoptive T-cell therapy (ACT) have been developed
rapidly and achieved great success in the clinic.
However, due to the
complex microenvironment and the cytokine storm, cures are still rare in the
treatment of solid tumors with ACT.
To solve this outstanding issue, Li
Tang, an Assistant Professor at the École Polytechnique Fédérale de Lausanne in Switzerland, has innovated a ground-breaking approach to substantially
improve both the safety and efficacy of ACT. In this strategy, T-cells
are “backpacked” with nanoparticles loaded with T-cell supporting drugs and the
drug release is triggered only when the T-cells encounter and recognize tumor
cells.
Specifically, he devised a “smart”
nanoparticle which can sense the change of chemical status (called “redox”
activity) on T-cell surfaces upon tumor cell encounter. Tumor cell recognition
leads to elevated T-cell activation status with increased membrane redox
activity.
In the meantime, Li Tang
also made new attempts in developing personalized precision cancer vaccines
against tumor specific targets. By using AI technology to predict
tumor-specific antigens, and reversibly polymerizing them, he prepared a personalized vaccine for precision
immunotherapy, which will hopefully benefit cancer patients using immunotherapy.
“I think immunotherapy
will be the most important and promising methods for curing cancer," Li
said.