Organ injury, such as acute kidney injury, ischemic stroke, and osteoarthritis, often results in complications that can be life-threatening or even fatal. Recently, many nanomaterials have emerged as promising repair agents for various organ injuries.
Dalong Ni focuses on the field of nanomaterial-based repair medicine (abbreviated as “nanorepair medicine”), by synthesizing new nanostructures/nanozymes and synergetic strategies for repairing acute liver/kidney/lung injury, inflammatory bowel disease, osteoarthritis/osteoporosis, etc., and revealing their repairing mechanism in vivo.
Ni leads a group named “Nanorepair Medicine” Lab, which is a creative and cooperative research team, aiming to repair different acute or chronic organ injuries using nanotechnology as a tool. His lab provides some innovative strategies for organ injury repair:
- scavenging reactive oxygen species directly to repair acute liver/kidney injury or chronic inflammatory bowel disease
- scavenging reactive oxygen species combined with gene therapy for repairing osteoarthritis
- regulating disease microenvironment with acid neutralization and immune regulation for osteoporosis reversion
Ni’s research provides valuable references for clinics since there is no effective methods/drugs for organ injury in clinics. Ni is working closely with doctors in Ruijing Hospital and pharmaceutical factory for translating medicine.